Table 2. Correlation between EGFR/CXCR4 expression and clinicopathologic factors in PDAC.
| Parameter | EGFR n (%) | P | CXCR4 n (%) | P | EGFR /CXCR4 n (%) | P | |||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Negative a | Positive b | ||||
| Overall | 67 (51.1) | 64 (48.9) | 63 (48.1) | 68 (51.9) | 98 (74.8) | 33 (25.2) | |||
| Age (years) | 0.163 | 0.223 | 0.842 | ||||||
| <60 | 27 (40.3) | 34 (53.1) | 33 (52.4) | 28 (41.2) | 45(45.9) | 16 (48.5) | |||
| ≥60 | 40 (59.7) | 30 (46.9) | 30 (47.6) | 40 (58.8) | 53 (54.1) | 17 (51.5) | |||
| Gender | 0.599 | 1.000 | 0.689 | ||||||
| Male | 40(59.7) | 35(54.7) | 27 (42.9) | 29 (42.6) | 43 (43.9) | 13 (39.4) | |||
| Female | 27 (40.3) | 29 (45.3) | 36 (57.1) | 39 (57.4) | 55 (56.1) | 20 (60.6) | |||
| Tumor sites | 1.000 | 0.583 | 0.536 | ||||||
| Head | 43 (64.2) | 42 (65.6) | 39 (61.9) | 46 (67.6) | 62 (63.3) | 23 (69.7) | |||
| Body/tail | 24 (35.8) | 22 (34.4) | 24 (38.1) | 22 (32.4) | 36 (36.7) | 10 (30.3) | |||
| Tumor size | 0.220 | 0.117 | 0.068 | ||||||
| T1–2 | 34(50.7) | 25 (39.1) | 33 (52.4) | 26 (38.1) | 49 (50.0) | 10 (30.3) | |||
| T3–4 | 33(49.3) | 39 (60.9) | 30 (47.6) | 42 (61.8) | 49 (50.0) | 23 (69.7) | |||
| Lymph node metastasis | 0.862 | 0.001 | 0.026 | ||||||
| No | 33 (49.3) | 30 (46.9) | 40 (63.5) | 23 (33.8) | 53 (54.1) | 10 (30.3) | |||
| Yes | 34 (50.7) | 34 (53.1) | 23 (36.5) | 45(66.2) | 45(45.9) | 23 (69.7) | |||
| TNM stage | 0.161 | 0.083 | 0.048 | ||||||
| I-II | 63 (94.0) | 56 (87.5) | 60 (95.2) | 59 (86.8) | 92 (93.9) | 27 (81.8) | |||
| III | 4 (6.0) | 8 (12.5) | 3 (4.8) | 9 (13.2) | 6 (6.1) | 6 (18.2) | |||
| Resection margins | 1.000 | 0.417 | 1.000 | ||||||
| Negative | 51 (76.1) | 49 (76.6) | 46 (73.0) | 54 (79.4) | 75 (76.5) | 25 (75.8) | |||
| Positive | 16 (23.9) | 15 (23.4) | 17 (27.0) | 14 (20.6) | 23 (23.5) | 8 (24.2) | |||
| Tumor differentiation | 0.031 | 0.206 | 0.004 | ||||||
| Well/moderate | 49 (73.1) | 35 (54.7) | 44 (69.8) | 40 (58.8) | 70 (71.4) | 14 (42.4) | |||
| Poor | 18 (26.9) | 29 (45.3) | 19 (30.2) | 28 (41.2) | 28 (28.6) | 19 (57.6) | |||
a Negative: single positive or both negative for EGFR and CXCR4.
b Positive: EGFR /CXCR4 coexpression (double positive for EGFR and CXCR4).