Table 3. Univariate analysis for disease-free survival and overall survival.
Parameter | DFS | OS | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |
Age (years) | 0.153 | 0.029 | ||||
<60 | 1 | 1 | ||||
≥60 | 1.31 | 0.89–1.94 | 1.58 | 1.03–2.42 | ||
Gender | 0.724 | 0.604 | ||||
Male | 1 | 1 | ||||
Female | 0.94 | 0.64–1.37 | 0.61 | 0.59–1.36 | ||
Tumor sites | 0.732 | 0.580 | ||||
Head | 1 | 1 | ||||
Body/tail | 1.07 | 0.72–1.59 | 1.13 | 0.73–1.76 | ||
Tumor size | 0.595 | 0.150 | ||||
T1–2 | 1 | 1 | ||||
T3–4 | 1.11 | 0.76–1.62 | 1.35 | 0.89–2.05 | ||
Lymph node metastasis | 0.020 | 0.006 | ||||
No | 1 | 1 | ||||
Yes | 1.55 | 1.05–2.28 | 1.77 | 1.16–2.71 | ||
TNM stage | <0.001 | <0.001 | ||||
I-II | 1 | 1 | ||||
III | 4.29 | 2.28–8.10 | 3.32 | 1.73–6.37 | ||
Resection margins | 0.022 | <0.001 | ||||
Negative | 1 | 1 | ||||
Positive | 1.64 | 1.05–2.56 | 2.24 | 1.28–3.89 | ||
Tumor differentiation | 0.000 | <0.001 | ||||
Well/moderate | 1 | 1 | ||||
Poor | 2.07 | 1.38–3.09 | 2.41 | 1.57–3.69 | ||
EGFR expression | 0.493 | 0.161 | ||||
Low | 1 | 1 | ||||
High | 1.14 | 0.78–1.66 | 1.34 | 0.88–2.03 | ||
CXCR4 expression | 0.003 | <0.001 | ||||
Low | 1 | 1 | ||||
High | 1.78 | 1.20–2.64 | 2.41 | 1.54–3.76 | ||
EGFR/CXCR4 coexpression | <0.001 | 0.001 | <0.001 | |||
Negative | 1 | 1 | ||||
Positive | 2.35 | 1.51–3.67 | 3.16 | 1.96–5.09 |