Table 1. Effect of 4 weeks daily oral administration of geraniol (GO; 250 mg/kg), pioglitazone (PIO; 5 and 10 mg/kg), and GO with PIO5 on intraperitoneal glucose tolerance test (IPGTT) in fructose-induced metabolic syndrome (MetS) in rats.
| Time (min) | Groups | |||||
|---|---|---|---|---|---|---|
| CONT | MetS | GO | PIO5 | PIO10 | GO/PIO5 | |
| 0 | 86.00±2.17 | 132.80±5.76* | 92.50±2.53# | 89.50±3.62# | 85.86±2.48# | 89.50±2.22# |
| 30 | 143.40±9.11 | 198.00±12.95 | 179.80±19.31 | 197.00±14.72 | 170.00±18.70 | 158.00±9.80 |
| 60 | 116.80±9.17 | 129.60±8.30 | 135.60 ±8.77 | 125.60±11.36 | 109.00±5.41 | 114.60±4.64 |
| 120 | 114.30±4.87 | 122.30±6.33 | 133.20±7.39 | 110.30±6.70 | 96.00±4.01 | 95.50 ±4.87 |
| AUC | 238.8±0.83 | 293.5±3.68* | 283.5±2.21*# | 266.4±2.73*# | 235.5±0.68# | 237.5±2.53# |
The fasting blood glucose titer (mg/dl) at different time intervals (0, 30, 60, and 120 min) after intraperitoneal glucose (2 g/kg) administration is presented as mean (6–8 animals) ± SEM, while the calculated area under the curve (AUC) of glucose is presented. P< 0.05, as compared to control (CONT) (*) and MetS (#) groups using one-way ANOVA followed by Tukey–Kramer test.