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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: RSC Adv. 2015;5(15):11577–11590. doi: 10.1039/C5RA00325C

Figure 8.

Figure 8

Scheme depicting the α-synuclein sequence and the binding loci for some inhibitors. The red area represents identified, potential β-structuring loci within (residues 67–82) and just to the N-terminus (residues 37–54) of the NAC region. Together these may represent the minimum sequence necessary for fibril formation. The green area represents the C-terminal region where binding of most inhibitors seems to occur. In some cases, binding at C-terminal sites has been associated with the formation of non-amyloid aggregates.