Table 2.

Extent of HFIP-induced α-syn amyloid formation in the presence of EGCG and peptides. The right-hand column converts these values to a %-inhibition value.

Inhibitor	Molar equiv.	Assay measure ( % of the uninhibited control)		%-Inhib.
		ThT fluor.	β-structure CD signature
RGAVVTGR-NH2	2	91± 15	74 ±23	< 25
EGCG	2	22± 7	38± 11	~ 65
Trp/Trp species
WW2	1	40± 16	57± 31	~ 50
	2	27± 11	20± 14	~ 75
WW2-DS	1	65± 16	84, 100	< 30
	2	49±21	64 ± 9	~ 50
cyclo-WW2	1	26± 13	22±14	~ 75
	2	8± 4	9± 7	> 90
cp-WW2	1	76± 15	52±22	~ 35
	2	34 ± 19	33± 16	~ 65
mWWhp	2	44 ± 9	51± 10	~ 50
cp-mWWhp	2	89±13	80± 7	< 20
RAVWW	2	37± 7	46± 10	~ 60
RW-HCH-WE	1	34 ± 10	36± 9	~ 65
	2	16± 11	25± 7	≥ 75
µPro1	2	37± 10	56± 10	~ 50
Tyr/Tyr species
RY-HCH-YE	2	37± 8	23, 26	~ 70
RY-VCI-YE	1	38, 44	55± 9	~ 50
	2	19± 7	22± 9	~ 80
AcY-VCI-YTG	2	27± 6	30± 11	~ 70
YY-µPro	1	11± 5	16± 8	~ 85
	2	8± 7	4, 5	≥90