Table 2.
Extent of HFIP-induced α-syn amyloid formation in the presence of EGCG and peptides. The right-hand column converts these values to a %-inhibition value.
| Inhibitor | Molar equiv. |
Assay measure ( % of the uninhibited control) |
%-Inhib. | |
|---|---|---|---|---|
| ThT fluor. | β-structure CD signature |
|||
| RGAVVTGR-NH2 | 2 | 91± 15 | 74 ±23 | < 25 |
| EGCG | 2 | 22± 7 | 38± 11 | ~ 65 |
| Trp/Trp species | ||||
| WW2 | 1 | 40± 16 | 57± 31 | ~ 50 |
| 2 | 27± 11 | 20± 14 | ~ 75 | |
| WW2-DS | 1 | 65± 16 | 84, 100 | < 30 |
| 2 | 49±21 | 64 ± 9 | ~ 50 | |
| cyclo-WW2 | 1 | 26± 13 | 22±14 | ~ 75 |
| 2 | 8± 4 | 9± 7 | > 90 | |
| cp-WW2 | 1 | 76± 15 | 52±22 | ~ 35 |
| 2 | 34 ± 19 | 33± 16 | ~ 65 | |
| mWWhp | 2 | 44 ± 9 | 51± 10 | ~ 50 |
| cp-mWWhp | 2 | 89±13 | 80± 7 | < 20 |
| RAVWW | 2 | 37± 7 | 46± 10 | ~ 60 |
| RW-HCH-WE | 1 | 34 ± 10 | 36± 9 | ~ 65 |
| 2 | 16± 11 | 25± 7 | ≥ 75 | |
| µPro1 | 2 | 37± 10 | 56± 10 | ~ 50 |
| Tyr/Tyr species | ||||
| RY-HCH-YE | 2 | 37± 8 | 23, 26 | ~ 70 |
| RY-VCI-YE | 1 | 38, 44 | 55± 9 | ~ 50 |
| 2 | 19± 7 | 22± 9 | ~ 80 | |
| AcY-VCI-YTG | 2 | 27± 6 | 30± 11 | ~ 70 |
| YY-µPro | 1 | 11± 5 | 16± 8 | ~ 85 |
| 2 | 8± 7 | 4, 5 | ≥90 | |