TABLE 2.

Local Maxima of Blood-Oxygen-Level-Dependent fMRI Signal Change During Word Encoding in Healthy Comparison Subjects and Patients With Schizophrenia^a

Group and Region	Estimated Brodmann’s Area	z Scoreb	Coordinatesc
			x	y	z
Comparison subjects (N=15)
Left superior frontal gyrus	10	4.28	−32	54	12
	9, 46	3.30	−28	42	28
Left inferior frontal gyrus	6, 44	6.11	−44	2	32
Right inferior frontal gyrus	9, 44	5.86	40	6	28
Right medial frontal gyrus	6	5.82	4	2	52
Left cingulate gyrus/cuneus	23	3.58	−12	−74	12
Left fusiform gyrus	37	5.42	−40	−62	−12
Right inferior occipital gyrus	18	4.89	40	−86	−8
Patients (N=14)
Left inferior frontal gyrus	44	3.66	−48	6	32
Left superior frontal gyrus	9	3.46	−32	54	32
	10	3.33	−28	58	24
Left precentral gyrus	4	5.70	−40	−10	56
Left postcentral gyrus	2	3.58	−52	−26	48
Right postcentral gyrus	3	3.23	56	−18	24
Left medial frontal gyrus	6	3.45	−4	−6	56
Left cingulate gyrus	32	3.12	0	18	36
Left superior temporal gyrus	22	3.96	−52	6	4
Right parahippocampal gyrus	28	3.52	24	−26	−8
Right thalamus		3.51	20	−26	0
Left inferior parietal lobule	40	3.65	−64	−30	28
Left fusiform gyrus	37, 19	6.21	−40	−58	−12
Comparison subjects > patients
Right middle frontal gyrus	46	4.61	40	38	16
Left middle/precentral gyrus	9, 6	3.09	−40	2	36
Left insula	13	4.88	−32	22	12
Right putamen		5.27	20	18	4
Left superior parietal lobule	7	3.39	−32	−70	52
Patients > comparison subjects
Left precentral gyrus	4	3.57	−28	−22	68
Left inferior temporal gyrus	37	4.09	−44	−42	−8
Right middle temporal gyrus	21	3.83	52	−34	0
Left parahippocampal gyrus	19	4.35	−28	−50	−4
Right parahippocampal gyrus	30	4.67	8	−42	−4
Right cuneus	17	4.25	20	−90	8
Right middle occipital gyrus	37	3.57	40	−66	4

^aValue during word encoding for correctly recognized words.

^bPeak activation in a cluster of at least eight voxels in which the difference in signal change exceeded an extent and threshold corrected p value of 0.05.

^cCoordinates from the stereotaxic atlas of Talairach and Tournoux (31).