TABLE 4.
Local Maxima of Blood-Oxygen-Level-Dependent fMRI Signal Change During Successful Word Retrieval in Healthy Comparison Subjects and Patients With Schizophreniaa
| Group and Region | Estimated Brodmann’s Area | z Scoreb | Coordinatesc
|
||
|---|---|---|---|---|---|
| x | y | z | |||
| Comparison subjects (N=15) | |||||
| Left middle frontal gyrus | 9 | 3.80 | −48 | 18 | 28 |
| Left inferior parietal gyrus | 40 | 3.70 | −56 | −34 | 36 |
| Right inferior parietal gyrus | 40 | 3.30 | 48 | −38 | 56 |
| Left precuneus | 7 | 3.38 | −16 | −66 | 48 |
| Right precuneus | 7 | 3.70 | 20 | −62 | 56 |
| Patients (N=13) | |||||
| Left orbital frontal gyrus | 11 | 3.46 | −8 | 30 | −28 |
| Right middle frontal gyrus | 11 | 3.36 | 36 | 34 | −16 |
| 11 | 3.22 | 8 | 54 | −16 | |
| Left middle frontal gyrus | 10 | 4.61 | −36 | 50 | 20 |
| Left precentral gyrus | 4 | 6.31 | −28 | −22 | 64 |
| Right precentral gyrus | 4 | 4.73 | 16 | −26 | 72 |
| Left middle temporal gyrus | 22 | 4.22 | 68 | −42 | 4 |
| Right fusiform gyrus | 20 | 3.99 | 44 | −22 | −24 |
| Left posterior cingulate | 3.08 | 0 | −50 | 8 | |
| Left middle occipital gyrus | 18 | 3.23 | −28 | −94 | 8 |
| Left superior parietal lobule | 7 | 3.64 | −28 | −50 | 44 |
| Right superior parietal lobule | 7 | 5.70 | 40 | −58 | 52 |
| Right precuneus | 7 | 3.40 | 12 | −66 | 36 |
| Comparison subjects > patients | |||||
| Right middle frontal gyrus | 9 | 3.11 | 40 | 18 | 36 |
| Patients > comparison subjects | |||||
| Left medial frontal gyrus | 11 | 3.61 | 8 | 54 | −16 |
| Right middle frontal gyrus | 11 | 3.66 | 36 | 34 | −16 |
| Left superior frontal gyrus | 8 | 3.33 | −36 | 22 | 48 |
| Left parahippocampal gyrus | 30 | 3.14 | −12 | −42 | −8 |
| Right middle temporal gyrus | 21 | 3.79 | 60 | −58 | 0 |
| Right inferior parietal lobule | 40 | 4.02 | 44 | −54 | 52 |
Value during word recognition for correct versus incorrect words.
Peak activation in a cluster of at least eight voxels in which the difference in signal change exceeded an extent and threshold corrected p value of 0.05.
Coordinates from the stereotaxic atlas of Talairach and Tournoux (31).