Table 2.
Differentially expressed miRNA in CCPRCC compared with normal matched tissue with log FC >2 and FDR <5%
| miRNA | logFC | P | FDR | Proposed function | Selected validated targets a | Reported elsewhere |
|---|---|---|---|---|---|---|
| miR-210 | 4.26 | 4.46 × 10−4 | 5.38E-04 | Hypoxamir | ISCU, HIF1A, MNT | [19] |
| miR-34a | 2.75 | 1.06 × 10−2 | 2.01E-03 | Oncosuppressor | AKT1, PTEN, c-MYC | [2] |
| miR-122 | 2.64 | 1.79 × 10−4 | 8.96E-03 | Oncosuppressor | CDKN2D, SMARCD1, CCND1 | [2,19] |
| miR-21 | 2.47 | 4.06 × 10−2 | 5.43E-03 | Oncogene | PTEN, TIMP3, PDCD4 | [2] |
| miR-34b* | 2.20 | 3.81 × 10−3 | 1.15E-03 | Oncosuppressor | VEGFA, CREB1, c-MYC | – |
| miR-489 | 2.16 | 2.26 × 10−3 | 2.50E-02 | Oncosuppressor | SRC, COMP, GHRHR | – |
| miR-4284 | −2.07 | 9.74 × 10−4 | 5.87E-04 | – | – | – |
| miR-1202 | −2.18 | 2.65 × 10−4 | 1.06E-02 | – | – | – |
| miR-135a | −2.24 | 2.22 × 10−4 | 1.03E-02 | Oncosuppressor | APC, JAK2, FLAP | [20] |
| miR-1973 | −2.61 | 2.11 × 10−3 | 2.44E-02 | – | – | – |
| miR-204 | −5.34 | 2.87 × 10−4 | 1.06E-02 | Oncosuppressor | VEGFA, RUNX2, E2F3 | [2] |
a
Experimentally proven gene targets listed in miRWalk and miRecords.