Table 3.

Selected differentially expressed miRNAs in CCPRCC, CCRCC, and PRCC

miRNA	CCPRCC	CCRCC	PRCC	Selected validated targets a
miR-210	Up	Up	NS	EFNA, MNT, VMP1
miR-155	Up	Up	NS	AGTR1, BACH1, LDOC1
miR106b	Up	Up	NS	E2F1, VEGFA, CDKN1A
miR-15a	Up	Up	NS	BCL2, VEGFA, PDCD4
miR-18a	Up	Up	NS	BIM, CTGF, ESR1
miR-130a	Up	NS	NS	–
miR135b	Up	NS	NS	APC
miR-101	Up	NS	NS	–
miR-10b	NS	Down	Down	HOXD10, KLF4, SFRS1
miR-141	NS	Down	-	CLOCK, SERBP1, ELMO2
miR-200a	NS	Down	Down	ZEB1, ZEB2, ELMO2
miR-200b	NS	Down	Down	ZEB1, ZEB2, ELMO2
miR-200c	NS	Down	Down	ZEB1, ERRFI1, JAG1
miR-26a	NS	Down	Down	SMAD1, PLAG1, TGFBR2
miR-218	NS	Down	Down	LAMB3, COL1A1, ECOP
miR-187	NS	Down	Down	–
miR-138	Down	Down	Down	RHOC, KRT, ROCK2
miR-422a	Down	NS	Down	–
miR-648	Down	NS	NS	–
miR-215	Down	NS	NS	DHFR, TYMS, DTL, WNK1
miR-663	Down	NS	NS	–
miR-204	Down	Down	NS	ARPC1B, MMP3, MMP9
miR-135a	Down	Down	NS	APC, FLAP, JAK2

Abbreviations: CCPRCC, clear cell papillary renal cell carcinoma; CCRCC, clear cell renal cell carcinoma; PRCC, papillary renal cell carcinoma;

^*experimentally proven gene targets listed in miRWalk and miRecords; NS, not significantly different compared with matched normal.

^aExperimentally proven gene targets listed in miRWalk and miRecords.