. Author manuscript; available in PMC: 2015 Feb 19.

Published in final edited form as: Prostate Cancer Prostatic Dis. 2013 Oct 22;17(1):64–69. doi: 10.1038/pcan.2013.49

Table 2.

Cox proportional hazards modeling of GC scores

Univariable	HR (95% CI)	P	Multivariable	HR (95% CI)	P
GC^a	1.62 (1.33–1.96)	<0.001	GC^a	1.40 (1.12–1.74)	0.003
Path Gleason Score^b ≥8	2.55 (1.14–5.69)	0.023	Path Gleason Score^b≥8	2.53 (0.94–6.83)	0.066
Pre-op PSA^c (log2)	1.15 (0.75–1.77)	0.531	Pre-op PSA^c (log2)	1.13 (0.78–1.64)	0.528
SVI	3.05 (1.36–6.85)	0.007	SVI	1.67 (0.62–4.47)	0.307
SM	0.55 (0.25–1.25)	0.157	SM	0.65 (0.27–1.59)	0.348
ECE	3.02 (1.31–6.96)	0.01	ECE	1.41 (0.59–3.38)	0.442
ttBCR	0.98 (0.749, 1.29)	0.9	ttBCR	1.11 (0.88,1.40)	0.365
LNI	5.22 (1.93–14.13)	0.001	LNI	0.59 (0.17–2.09)	0.417

Abbreviations: CI, confidence interval; ECE, extra-capsular extension; GC, genomic classifier; LNI, lymph node involvement; SM, surgical margin; SVI, seminal vesicle invasion; ttBCR, time to biochemical recurrence.

Hazard ratio reported for 10% increase of GC score.

Pathological Gleason Score was dichotomized to compare Gleason Score ≥8 to Gleason Score ≤7.

Hazard ratio reported for 10% increase of log-transformed level.