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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: AJR Am J Roentgenol. 2014 Oct;203(4):897–903. doi: 10.2214/AJR.14.12497

TABLE 5.

Cox Multivariate Analysis for Primary-Tumor Metabolic Tumor Volume (MTV)—Model II

Parameter Event-Free Survivala
p
Hazard Ratio 95% CI
Primary-tumor MTV(per mL) 1.020 1.00–1.04 0.031
Age (per y) 1.083 0.99–1.18 0.069
Primary-tumor MTV (per mL) 1.024 1.01–1.04 0.012
Sex (male vs female) 0.248 0.06–1.05 0.058
Primary-tumor MTV (per mL) 1.024 1.01–1.04 0.011
Race 0.247 0.06–1.17 0.181
Primary-tumor MTV (per mL) 1.021 1.00–1.04 0.028
Smoking (smoker vs nonsmoker) 1.214 0.30–4.96 0.787
Primary-tumor MTV (per mL) 1.020 1.00–1.04 0.034
Stageb (III vs IV) 0.690 0.08–5.74 0.731
Primary-tumor MTV (per mL) 1.017 1.00–1.04 0.076
Nodal status (positive vs negative) 3.891 1.01–14.99 0.048
Primary-tumor MTV (per mL) 1.022 1.00–1.04 0.019
Treatment (CRT vs no CRT) 1.711 0.34–8.70 0.517
Primary-tumor MTV (per mL) 1.022 1.01–1.04 0.013
SUVmax 0.918 0.78–1.09 0.322
Primary-tumor MTV (per mL) 1.021 1.00–1.04 0.022
SUVmean 0.929 0.68–1.28 0.649
Primary-tumor MTV (per mL) 1.017 1.00–1.04 0.078
SUVpeak 0.885 0.70–1.13 0.320

Note—Primary-tumor MTV remained significant when adjusted for other clinical and imaging parameters, except for neck nodal status and SUVpeak. SUVmax = maximum standardized uptake value, SUVmean = mean standardized uptake value, SUVpeak = peak standardized uptake value, CRT = chemoradiation therapy.

a

Includes recurrence-free and overall survival.

b

Stages III and IV describe advanced cancers in the classification of the American Joint Committee on Cancer [12].