Figure 4.

Maps of age effects on growth rates. A, Partial correlation coefficient maps for interaction between age effect and diagnosis in white matter (B₄). B, P maps of significance for interaction between age effect and diagnosis in white matter (B₄). C, Derived age effects in siblings of patients with childhood-onset schizophrenia (COS) corrected for multiple comparisons inside the white matter of each brain lobe (B₁ + B₄). White matter growth rates slow with age in nonpsychotic siblings of patients with COS. The color bar shows the annual rate of change in the growth rate (in percentage) per year. The red colors show that the annual growth rate drops by approximately 0.2% to 0.8% per year, less than those in healthy controls. Standard radiologic convention was used to display the images.