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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: Addict Biol. 2013 Jun 13;19(6):986–995. doi: 10.1111/adb.12067

Figure 2.

Figure 2

Fluoxetine potentiation of repeated methylphenidate-induced Zif268 and Homer1a blunting in the middle striatum. Mean density values (mean ± SEM) for Zif268 (A) and Homer1a expression (B) in rats that received 5 injections of vehicle (V), methylphenidate (5 mg/kg; MP), fluoxetine (5 mg/kg; FLX), or methylphenidate + fluoxetine (MP+FLX), followed on day 6 by a vehicle or cocaine challenge (25 mg/kg; C), are given for the medial (m), ventral (v), dorsal (d), central (c), dorsolateral (dl), and ventrolateral (vl) sectors. The potentiation of blunting displayed a medial-lateral gradient, with the most robust effects laterally. *P<0.05, **P<0.01 and ***P<0.001 vs. V/C; #P<0.05, ##P<0.01 and ###P<0.001, MP+FLX/C vs. MP/C (potentiation).