Table 3.
Comparison of the performance of DETECT versus ESC/ERS versus ASIG screening models for pulmonary arterial hypertension in patients with systemic sclerosis
| PAH prevalence set at 10% a | ||||||
|---|---|---|---|---|---|---|
| DETECT | ESC/ERS | ASIG | DETECT | ESC/ERS | ASIG | |
| n = 61 | n = 58 | n = 37 | n = 61 | n = 58 | n = 37 | |
| Positive b | 49 (80.3) | 48 (82.8) | 25 (67.6) | |||
| Negative b | 12 (19.7) | 10 (17.2) | 12 (32.4) | |||
| True PAH on RHC c | 27 (44.3) | 27 (46.55) | 15 (40.54) | |||
| Sensitivity | 100% | 96.3% | 100% | 100% | 96.3% | 100% |
| (95% CI) | (87.2-100) | (81.0-99.9) | (78.2-100) | (54.1-100) | (54.1-100) | (39.8-100) |
| Specificity | 35.3% | 32.3% | 54.5% | 35.3% | 32.3% | 54.5% |
| (95% CI) | (19.7-53.5) | (16.7-51.4) | (32.2-75.6) | (23.8-50.4) | (15.6-41.0) | (33.5-69.2) |
| PPV | 55.1% | 55.3% | 60% | 14.7% | 13.6% | 19.6% |
| (95% CI) | (40.2-69.3) | (40.1-69.8) | (38.7-78.8) | (5.6-29.2) | (5.2-27.4) | (5.7-43.7) |
| NPV | 100% | 90.9% | 100% | 100% | 98.7% | 100% |
| (95% CI) | (63.1-100) | (58.7-99.8) | (73.5-100) | (83.2-100) | (76.8-100) | (80.5-100) |
aRefer to Additional file 1. bPositive or negative number screened by each of the algorithms. Values are presented as number (percentage). cTrue pulmonary arterial hypertension (PAH) number confirmed by right heart catheterization (RHC). Values are presented as number (percentage). ASIG, Australian Scleroderma Interest Group; CI, confidence interval; ESC/ERS, European Society of Cardiology/European Respiratory Society; NPV, negative predictive value; PPV, positive predictive value.