Table 4.
Comparison of the performance of DETECT versus ESC/ERS versus ASIG screening models for precapillary pulmonary hypertension and pulmonary hypertension in patients with systemic sclerosis
| Precapillary PH a versus non-PH | PH b versus non-PH | |||||
|---|---|---|---|---|---|---|
| DETECT | ESC/ERS | ASIG | DETECT | ESC/ERS | ASIG | |
| n = 69 | n = 66 | n = 42 | n = 73 | n = 70 | n = 46 | |
| Positive c | 56 (81.2) | 57 (86.4) | 30 (71.4) | 60 (82.2) | 61 (87.1) | 33 (71.7) |
| Negative c | 13 (18.8) | 9 (13.6) | 12 (28.6) | 13 (17.8) | 9 (12.9) | 13 (28.3) |
| True PAH On RHC d | 35 (50.7) | 35 (53.0) | 20 (47.6) | 39 (53.4) | 39 (55.7) | 24 (52.2) |
| Sensitivity | 97.1% | 97.1% | 100% | 97.4% | 97.4% | 95.8% |
| (95% CI) | (85.1-99.9) | (85.1-99.9) | (83.2-100) | (86.5-99.9) | (86.5-99.9) | (78.9-99.9) |
| Specificity | 35.3% | 25.8% | 54.5% | 35.3% | 25.8% | 54.5% |
| (95% CI) | (19.7-53.5) | (11.9-44.6) | (32.2-75.6) | (19.7-53.5) | (11.9-44.6) | (32.2-75.6) |
| PPV | 60.7% | 59.6% | 66.7% | 63.3% | 62.3% | 69.7% |
| (95% CI) | (46.8-73.5) | (45.8-72.4) | (47.2-82.7) | (49.9-75.4) | (49.0-74.4) | (51.3-84.4) |
| NPV | 92.3% | 88.9% | 100% | 92.3% | 88.9% | 92.3% |
| (95% CI) | (64.0-99.8) | (51.8-99.7) | (73.5-100) | (64.0-99.8) | (51.8-99.7) | (64.0-99.8) |
aPrecapillary pulmonary hypertension (PH) means World Health Organization (WHO) group 1 (PAH) and 3 (lung disease/hypoxia-associated) PH. bPH means WHO 1, 2 (left heart disease-associated), and 3 PH. cPositive or negative number screened by each of the algorithms. Values are presented as number (percentage). dTrue PAH number confirmed by right heart catheterization (RHC). Values are presented as number (percentage). ASIG, Australian Scleroderma Interest Group; CI, confidence interval; ESC/ERS, European Society of Cardiology/European Respiratory Society; NPV, negative predictive value; PAH, pulmonary arterial hypertension; PPV, positive predictive value.