Table 3.
Above-background cytokine responses to αGalCer at 5 days post-stimulation
| Analyte | HIV-negative (n = 14) | HIV+ ART naïve (n = 8) | HIV+ ART experienced (n = 14) | p value ** | Post-test differences *** | |
|---|---|---|---|---|---|---|
| IFNγ | N Detectible | 13 | 7 | 8 | 0.057 | |
| Concentration* | 345.9 (76.74, 2115) | 34.97 (4.83, 142.7) | 2.275, (0.0, 124.8) | 0.003 | HIV-N vs HIV+ ART | |
| IL-4 | N Detectible | 7 | 3 | 2 | 0.129 | |
| Concentration* | 3.06 (0.0, 22.02) | 0.0 (0.0, 6.69) | 0.0 (0.0, 0.18) | 0.095 | ||
| IL-10 | N Detectible | 4 | 2 | 6 | 0.618 | |
| Concentration* | 0.0 (0.0, 5.82) | 0.0 (0.0, 4.25) | 0.0 (0.0, 13.8) | 0.683 | ||
| IL-13 | N Detectible | 11 | 5 | 6 | 0.152 | |
| Concentration* | 199.1 (19.23, 477.0) | 8.26 (0.11, 77.2) | 0.0 (0.0, 25.45) | 0.014 | HIV-N vs HIV+ ART | |
| IP-10 | N Detectible | 11 | 6 | 5 | 0.005 | |
| Concentration* | 1586 (836.8, 6168) | 329.3 (24.5, 5351) | 0.0 (0.0, 409.6) | 0.001 | HIV-N vs HIV+ ART | |
| MIP-1α | N Detectible | 6 | 4 | 4 | 0.409 | |
| Concentration* | 0.0 (0.0, 198.4) | 37.2 (0.0, 158.5) | 0.0 (0.0, 75.6) | 0.453 | ||
| MIP-1β | N Detectible | 8 | 4 | 4 | 0.368 | |
| Concentration* | 78.16 (0.0, 370.2) | 35.06 (0.0, 165.1) | 0.0 (0.0, 104.6) | 0.253 | ||
| TNFα | N Detectible | 10 | 7 | 6 | 0.084 | |
| Concentration* | 52.34 (0.0, 317.1) | 20.2 (4.74, 115.1) | 0.065 (0.0, 140.2) | 0.370 | ||
*Data are presented as median (IQR) in pg/mL.
**p values obtained from Chi squared tests for N detectible data, Kruskal-Wallis tests for concentration comparisons.
***Dunn’s post-test comparisons with p < 0.05 are indicated for each significant Kruskal-Wallis result Statistical tests with p ≤ 0.1 (trend) are indicated in bold.