Table 3.
Adverse Event | Total (n = 291)a | LAI-R (n = 143) | Oral Second-Generation Antipsychotics (n = 148) | Test and Significance of Difference |
---|---|---|---|---|
Bruising easily | 1.45±0.71 | 1.43±0.67 | 1.48±0.75 | t = −0.64, P = .52 |
Rash | 1.48±0.74 | 1.53±0.78 | 1.44±0.71 | t = 1.06, P = .29 |
Urticaria (hives, itching) | 1.66±0.77 | 1.60±0.69 | 1.71±0.84 | t = −1.20, P = .23 |
Blurred vision | 1.84±0.79 | 1.76±0.73 | 1.91±0.83 | t = −1.63, P = .10 |
Sedation/drowsiness | 2.43±0.83 | 2.34±0.87 | 2.53±0.78 | t = −1.90, P = .058 |
Restlessness | 2.45±0.79 | 2.48±0.76 | 2.43±0.82 | t = 0.47, P = .64 |
Insomnia | 2.37±0.92 | 2.38±0.89 | 2.36±0.94 | t = 0.18, P = .86 |
Malaise (weakness, fatigue) | 2.18±0.86 | 2.22±0.85 | 2.14±0.87 | t = 0.75, P = .46 |
Stiffness | 1.99±0.84 | 2.01±0.82 | 1.97±0.85 | t = 0.49, P = .63 |
Tremor | 1.76±0.76 | 1.77±0.72 | 1.75±0.80 | t = 0.22, P = .83 |
Dizziness | 1.80±0.81 | 1.82±0.79 | 1.78±0.82 | t = 0.43, P = .66 |
Headache | 1.94±0.89 | 1.99±0.88 | 1.89±0.90 | t = 1.04, P = .30 |
Fever | 1.25±0.47 | 1.27±0.49 | 1.24±0.46 | t = 0.53, P = .60 |
Sore throat | 1.60±0.74 | 1.64±0.78 | 1.57±0.69 | t = 0.72, P = .47 |
Dry mouth | 2.31±0.93 | 2.36±0.92 | 2.25±0.94 | t = 1.04, P = .30 |
Hypersalivation | 1.80±0.87 | 1.76±0.80 | 1.84±0.94 | t = −0.74, P = .46 |
Enuresis | 1.59±0.86 | 1.63±0.89 | 1.56±0.83 | t = −0.68, P = .50 |
Constipation | 1.69±0.84 | 1.75±0.86 | 1.64±0.82 | t = 1.08, P = .28 |
Diarrhea | 1.66±0.83 | 1.65±0.86 | 1.68±0.81 | t = −0.26, P = .80 |
Anorexia (loss of appetite) | 1.77±0.85 | 1.89±0.86 | 1.69±0.84 | t = 2.00, P = .046 |
Nausea | 1.75±0.81 | 1.78±0.82 | 1.72±0.80 | t = 0.70, P = .48 |
Vomiting | 1.49±0.74 | 1.48±0.72 | 1.51±0.76 | t = −0.44, P = .66 |
Menstrual irregularity (N = 122) | 1.58±0.91 | 1.62±0.96 | 1.55±0.86 | t = 0.41, df = 120, P = .68 |
Breast tenderness/galactorrhea (N = 290) | 1.36±0.65 | 1.39±0.69 | 1.32±0.61 | t = 0.91, df = 288, P = .36 |
Note: LAI-R, long-acting injectable risperidone. Only subjects with postbaseline ratings are included.
a N = 291 (LAI-R: 143, Oral second-generation antipsychotics: 148), all t tests have df = 289 except as noted.