Figure 1. A transgenic mouse model of OI type V.
A transgenic construct of mutant Ifitm5 (c.−14C>T) and wild type Ifitm5 (control) under the Col1a1 2.3 kb promoter expresses in osteoblasts. (A). Quantitative real time PCR indicates overexpression of Ifitm5 in wild type transgenic lines (WT Tg) compared to non-transgenic (NT) littermates (B). Quantitative real time PCR shows overexpression of Ifitm5 in mutant transgenic lines (Mut Tg) compared to non-transgenic (NT) littermates (C). Data in (B, C) are means ± SD.