Table 3.

Analyses of effect modification of the association of depression, CIND and dementia with odds of ischemic stroke

	Odds Ratio (95% Confidence Interval)
Depression/CIND/Dementia × Sex (n = 6,969)
Depression alone × Female	1.34 (0.80, 2.24)
CIND alone × Female	1.63 (1.08, 2.48)*
Dementia alone × Female	1.60 (0.91, 2.80)
Depression + CIND × Female	1.27 (0.71, 2.26)
Depression + Dementia × Female	1.83 (0.89, 3.74)
Depression/CIND/Dementia × Dual Medicare-Medicaid status (n = 6,969)
Depression alone × Dual Medicare-Medicaid	1.43 (0.79, 2.58)
CIND alone × Dual Meaicare-Medicaid	1.75 (1.04, 2.94)*
Dementia alone × Dual Medicare-Medicaid	1.43 (0.78, 2.62)
Depression + CIND × Dual Medicare-Medicaid	1.24 (0.67, 2.30)
Depression + Dementia x Dual Medicare-Medicaid	2.19 (1.06, 4.54)*
Depression/CIND/Dementia × Baseline cerebrovascular disease (n = 6,969)
Depression alone × Prior cerebrovascular disease	0.97 (0.35, 2.67)
CIND alone × Prior cerebrovascular disease	2.13 (0.91, 5.01)
Dementia alone × Prior cerebrovascular disease	2.43 (1.08, 5.45)*
Depression + CIND × Prior cerebrovascular disease	1.13 (0.42, 3.04)
Depression + Dementia × Prior cerebrovascular disease	1.09 (0.43, 2.79)
Depression/CIND/Dementia × Baseline diabetes (n = 6,969)
Depression alone × Baseline diabetes	0.73 (0.30, 1.75)
CIND alone × Baseline diabetes	1.02 (0.47, 2.22)
Dementia alone × Baseline diabetes	1.50 (0.65, 3.44)
Depression + CIND × Baseline diabetes	1.79 (0.81, 3.96)
Depression + Dementia × Baseline diabetes	0.77 (0.30, 2.01)
Depression/CIND/Dementia × Baseline hypertension (n = 6,969)
Depression alone × Baseline hypertension	0.76 (0.43, 1.37)
CIND alone × Baseline hypertension	1.27 (0.76, 2.13)
Dementia alone × Baseline hypertension	1.56 (0.85, 2.84)
Depression + CIND × Baseline hypertension	0.91 (0.49, 1.68)
Depression + Dementia × Baseline hypertension	1.46 (0.72, 2.96)

Abbreviation: CIND = cognitive impairment without dementia

^*P < 0.05