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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Biol Psychiatry. 2014 Aug 27;77(6):589–596. doi: 10.1016/j.biopsych.2014.08.012

Figure 3.

Figure 3

PRS downregulates the expression of BDNF transcripts in the FC and HP of adult offspring. A). Mouse Bdnf gene structure and alternative transcripts. Exons are shown as boxes and introns are shown as thick lines. Protein coding regions are shown as solid boxes and untranslated regions are shown as empty boxes. Each of the eight 5′ untranslated exons is spliced to the common 3′ protein coding exon IX (41). In B and C, BDNF transcripts (III, IV, VI and IX) at PND 75 in the FC, and HP of PRS offspring are significantly decreased as compared to the NS group. Data are presented as mean ± SEM of 12 mice. * p < .05 (Student’s t-test) vs. the corresponding NS value.