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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cell Signal. 2015 Jan 10;27(3):487–497. doi: 10.1016/j.cellsig.2015.01.004

Fig. 6.

Fig. 6

Cyclopamine suppresses endometrial response to P4 and E2 produced from JEG-3 choriocarcinoma xenografts in ovariectomized nude mice. (A–C) Representative gross morphology of uterus and xenografts from ovariectomized nude mice subcutaneously inoculated with JEG-3 cells, and treated with indicated dosages of cyclopamine for 12 d after 10 d of inoculation. (D, E) Tumor and uterine weights in ovariectomized nude mice with same treatments. (F, G) Human P4 and E2 levels in circulation of ovariectomized nude mice with same treatments. (H–K) HE staining for uterus from ovariectomized nude mice with same treatments. G, glandularepithelium; L, lumen; LE, luminal epithelium; M, myometrium; S, stroma.**, ‡p<0.01, † p<0.05; n=6, error bar, SD.