Table 2.

Twenty most significant upstream regulators in HBEC30KT-shTP53 versus HBEC30KT.

Upstream Regulator	Molecule Type	Activation z- score	p-value of overlap
TNF	cytokine	7.189	6.18×10−55
TGFB1	growth factor	−2.258	1.10×10−50
IFNG	cytokine	8.041	9.68×10−45
lipopolysaccharide	chemical drug	7.310	3.25×10−42
NKX2-3	transcription regulator	−4.911	1.86×10−41
TP53	transcription regulator	−3.677	2.93×10−38
MAPK1	kinase	−4.847	1.46×10−31
OSM	cytokine	4.194	3.00×10−31
IL1B	cytokine	5.596	7.98×10−31
dexamethasone	chemical drug	−6.822	1.35×10−29
HRAS	enzyme	2.353	1.05×10−26
NFkB (complex)	complex	6.191	3.39×10−26
IFNL1	cytokine	6.570	1.40×10−23
IFNA2	cytokine	6.380	2.42×10−23
poly rI:rC-RNA	chemical reagent	7.265	1.99×10−22
TLR3	transmembrane receptor	4.977	5.75×10−22
TP63	transcription regulator	3.700	2.09×10−21
STAT3	transcription regulator	2.076	3.20×10−21
EZH2	transcription regulator	3.200	8.20×10−21
CHUK	kinase	3.898	1.46×10−20