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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Anesthesiology. 2015 Mar;122(3):537–550. doi: 10.1097/ALN.0000000000000582

Figure 3. Gene Ontology (GO) group disruption a) Oxidoreductase activity and b) Oxygen transport.

Figure 3

Figure 3

Shown are the two groups with the most pronounced disruption of a functional category in the GO ANOVA, implying changes in the pattern of gene expression within the functional group and potential disruption of normal operation of the group. The hemoglobin genes hemoglobin α1 (HBA1) and hemoglobin beta (HBB) disrupt the molecular function group oxidoreductase activity and oxygen transport. While the expression of the majority of genes in these categories is very similar between baseline and postischemia, HBB and HBA1 are significantly upregulated compared to all other genes in this category (disruption P < 0.001).