Table 2.

Shown Are Top Up and Down-regulated Genes between Postischemia and Baseline for the Ventricle at Baseline, Postischemia, and for the Atrium at Baseline

Gene Symbol	Gene Name	P-value	Fold Change (Post vs. Baseline)	Baseline (N=45)	Postischemia (N=45)	Atrium (N=6)
ITLN1	intelectin 1 (galactofuranose binding)	0.009	−4.08	262.3±548.8	45.7±121.8	242.4 ± 392.1
SLPI	secretory leukocyte peptidase inhibitor	0.008	−3.65	26.5±52.4	5.4±13.7	10.5 ± 13.2
PRG4	proteoglycan 4	0.003	−3.63	13.7±23.2	3.1±8.2	13 ± 20
CCL21	chemokine (C-C motif) ligand 21	0.003	−3.36	21.3±35.6	5.2±6.4	NA
HP	haptoglobin	0.01	−3.22	25.6±51.3	5.9±14	15 ± 17.2
MGST1	microsomal glutathione S-transferase 1	0.008	−2.89	12.4±22.9	3.3±4.3	29.8 ± 45.3
C3	complement component 3	0.002	−2.5	53.5±68.8	19.3±29.3	60 ± 55.3
LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	0.001	−2.49	9.2±14	2.8±2.8	10.7 ± 7.7
F13A1	coagulation factor XIII, A1 polypeptide	0.005	−2.18	12.6±21.4	4.5±5.3	6.8 ± 5.4
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.001	3.06	7.9±12.3	27.4±37.5	61 ± 80.5
S100A8	S100 calcium binding protein A8	4.76E-05	2.8	7.3±7.1	20.5±20.3	41.3 ± 66.1
HBA2	hemoglobin, alpha 2	0.004	3.09	302.8±242.7	917.1±1349.5	NA
HBA1	hemoglobin, alpha 1	7.47E-06	2.65	262±248.8	594.7±506.6	321.8 ± 292
HBB	hemoglobin, beta	0.004	2.72	237.7±188	730.6±1120.1	229.7 ± 143.5
S100A9	S100 calcium binding protein A9	0.001	2.23	16±13	36.7±38.1	NA
ZFP36	ZFP36 ring finger protein	0.002	2.06	10.5±11.2	22.5±24	NA

Shown are all genes with a mean reads per kilobase of transcript per million mapped reads (RPKM) >5, a fold change ≥ 2 and a FDR P<0.05. Genes are in a multivariate model adjusting for time of sample (baseline versus post-ischemia), center where RNA-sequencing was performed, and minutes of aortic cross-clamping (AXC = effective ischemia time). (red, up-regulated; green, down-regulated). Genes are sorted by fold change. FDR = false discovery rate.