Table 3.
Risk of Hip Fracture, Dementia, and Total Mortality for a One Unit Higher TSH, FT4, or Total T3
| Model | No. of Events/No. at Risk | TSH, mU/L |
Free T4, pmol/L |
Total T3, nmol/L |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | ||
| Hip fracture | 340/2803 | |||||||||
| Model 1 | 0.93 | 0.83–1.04 | .20 | 0.99 | 0.94–1.05 | .79 | 1.07 | 0.74–1.55 | .73 | |
| Model 2 | 0.94 | 0.84–1.05 | .26 | 0.98 | 0.94–1.04 | .56 | 1.03 | 0.71–1.51 | .86 | |
| Dementia | 229/1824 | |||||||||
| Model 1 | 0.87 | 0.76–1.00 | .05 | 1.04 | 0.97–1.10 | .26 | 1.01 | 0.63–1.59 | .98 | |
| Model 2 | 0.88 | 0.76–1.01 | .07 | 1.02 | 0.96–1.09 | .52 | 1.06 | 0.66–1.68 | .81 | |
| Total Mortality | 2161/2843 | |||||||||
| Model 1 | 0.95 | 0.91–0.99 | .03 | 1.03 | 1.01–1.05 | .007 | 1.12 | 0.97–1.30 | .12 | |
| Model 2 | 0.96 | 0.91–1.00 | .05 | 1.01 | 0.99–1.03 | .17 | 1.12 | 0.96–1.30 | .15 | |
Model 1 for hip fracture and total mortality are adjusted for age, sex, race, and initiation of thyroid meds (time varying). Model 1 for dementia also includes an age2 term.
Model 2 for hip fracture additionally adjusted for oral steroid use, kilocalories of exercise (ln), current smoking, alcohol use, and weight.
Model 2 for dementia additionally adjusted for body mass index (BMI), hypertension, diabetes, current smoking, any alcohol use, total cholesterol, stroke history, claudication, and apoe4 genotype.
Model 2 for mortality additionally adjusted for BMI, hypertension, diabetes, current smoking, coronary heart disease, heart failure, stroke, claudication, depression score, creatinine, and kcal of activity.