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. 2014 Dec 12;100(3):E531–E541. doi: 10.1210/jc.2014-3399

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This article has been published under the terms of the Creative Commons Attribution License (CC-BY: https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the Endocrine Society the exclusive right to publish the article and identify itself as the original publisher.

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Figure 3. — Pedigree (A) and sagittal and coronal magnetic resonance images of the pituitary adenoma (B) are shown. C, H&E-stained section (×20) shows that the tumor of patient 5 contains multiple vacuoles. D, The immunoreaction with the anti-113-1 antibody (immunoperoxidase, ×20) highlights the mitochondria content. E, SDHB immunostaining shows loss of expression in neoplastic cells, whereas endothelial cells (arrow) retain the expression (immunoperoxidase, ×20). Loss of the SDHB gene in germline and pituitary tumor tissue in patient 5. F, Germline DNA shows a deletion affecting MLPA SDHB probes 6–8 in DNA derived from leukocytes. G, In pituitary adenoma tissue, a complete loss of genetic material at the SDHB probes 6–8 area and heterozygous loss of SDHB probes 1–5.