Table 1.
Participants' Characteristics and Baseline Measurements
| Trial | Sexual Function | Vitality | Physical Function | Overall |
|---|---|---|---|---|
| N | 470 | 474 | 390 | 788b |
| Age (y)a | 71.6 ± 5.3 | 71.9 ± 5.8 | 73.3 ± 6.2 | 72.2 ± 5.7 |
| Hypertension (%) | 71.3 | 73.0 | 73.9 | 71.5 |
| Diabetes (%) | 35.0 | 35.7 | 42.6 | 36.9 |
| BMI | 31.0 ± 3.5 | 31.0 ± 3.6 | 31.6 ± 3.4 | 31.0 ± 3.5 |
| WC | 110 ± 10.7 | 110.7 ± 10.4 | 112.4 ± 11.3 | 110.5 ± 10.8 |
| TT (ng/dL) | 238.2 ± 69.0 | 237.3 ± 70.4 | 235.1 ± 67.4 | 238.1 ± 68.9 |
| FT (pg/mL) | 58.3 ± 20.2 | 58.1 ± 20.2 | 57.0 ± 20.2 | 58.2 ± 20.3 |
| E2 (pg/mL) | 22.6 ± 9.7 | 23.2 ± 9.9 | 23.4 ± 9.0 | 23.1 ± 9.7 |
| SHBG (nmol/L) | 30.6 ± 15.5 | 31.6 ± 17.1 | 32.0 ± 16.6 | 31.2 ± 16.1 |
| DISF-SDD | 11.8 ± 6.6 | 14.0 ± 7.9 | 14.3 ± 8.1 | 14.0 ± 7.8 |
| IIEF-EFD | 8.0 ± 8.2 | 7.4 ± 7.8 | 6.9 ± 7.7 | 7.9 ± 8.2 |
| PDQ | 1.4 ± 1.3 | 1.5 ± 1.4 | 1.4 ± 1.3 | 1.5 ± 1.4 |
| FACIT-Fatigue | 37.8 ± 8.9 | 31.4 ± 6.4 | 37.5 ± 8.4 | 36.9 ± 8.7 |
| PHQ-9 | 4.9 ± 3.9 | 6.6 ± 4.0 | 5.5 ± 4.0 | 5.4 ± 4.0 |
| Gait speed (m/s) | 1.1 ± 0.2 | 1.1 ± 0.2 | 0.96 ± 0.19 | 1.1 ± 0.2 |
| PF-10 | 75.6 ± 20.4 | 70.4 ± 19.9 | 65.4 ± 20.4 | 72.1 ± 20.6 |
Abbreviations: BMI, body mass index; WC, waist circumference; Total T, total testosterone; Free T, free testosterone; E2, estradiol; DISF-SDD, Derogatis Interview for Sexual Function-Sexual Desire Domain; PF-10, Physical Function Subscale.
a
Mean ± sd.
b
Seven hundred ninety men were enrolled, but 2 were deemed ineligible and are not included here.