Table 2.

Association of Hormones With Sexual Function, Vitality, and Physical Function

Outcome	Total T		Free T		Estradiol		SHBG
	ß (95% CI)	P	ß (95% CI)	P	ß (95% CI)	P	ß (95% CI)	P
Sexual Functiona
(Sexual Function Trial Only)
DISF	0.009 (0.001, 0.018)	0.034	0.037 (0.006, 0.068)	0.020	0.035 (−0.028, 0.097)	0.275	−0.016 (−0.059, 0.023)	0.469
IIEF	0.016 (0.005, 0.027)	0.004	0.056 (0.017, 0.094)	0.005	0.047 (−0.030, 0.124)	0.230	−0.049 (−0.102, 0.005)	0.074
PDQ-Q4	0.002 (0.000, 0.004)	0.024	0.008 (0.002, 0.014)	0.014	0.012 (−0.000, 0.024)	0.051	−0.006 (−0.014, 0.003)	0.185
Sexual Functiona
(All T-Trial Participants)
DISF	0.008 (−0.000, 0.016)	0.055	0.048 (0.020, 0.077)	<0.001	0.060 (0.003, 0.117)	0.039	−0.047 (−0.085, −0.009)	0.016
IIEF	0.014 (0.004, 0.246)	0.005	0.049 (0.013, 0.085)	0.008	0.047 (−0.023, 0.122)	0.218	−0.046 (−0.097, 0.004)	0.073
PDQ-Q4	0.002 (0.000, 0.003)	0.026	0.008 (0.003, 0.013)	0.003	0.012 (0.002, 0.022)	0.022	−0.006 (−0.013, 0.001)	0.078
Vitality Trialb
FACIT Fatigue	0.005 (−0.003, 0.013)	0.217	0.000 (−0.030, 0.031)	0.982	0.001 (−0.058, 0.061)	0.962	0.016 (−0.022, 0.054)	0.401
PHQ-9	−0.003 (−0.008, 0.002)	0.290	−0.006 (−0.026, 0.013)	0.527	−0.009 (−0.046, 0.029)	0.657	0.012 (−0.013, 0.036)	0.347
Physical Function Trialb
Gait Speed (m/s)	0.000 (−0.000, 0.000)	0.314	0.001 (−0.000, 0.002)	0.231	−0.002 (−0.004, 0.000)	0.104	−0.001 (−0.002, 0.000)	0.112
PF-10	−0.003 (−0.033, 0.027)	0.824	0.004 (−0.100, 0.108)	0.938	−0.311 (−0.530, −0.092)	0.006	−0.068 (−0.199, 0.063)	0.308

Abbreviations: DISF, Derogatis Interview for Sexual Function-Sexual Desire Domain.

^aAdjusted for BMI, age, hypertension, diabetes, and waist circumference.

^bAdjusted for age and BMI.