Skip to main content
. 2014 Nov 25;100(3):E463–E468. doi: 10.1210/jc.2014-2357

Table 4.

Logistic Regression Analysis Comparing Amino Acids of T2D Converters and Nonconverters

Metabolite, μmol/L Nonconverter (n = 70)
 T2D Converter (n = 76)
 T2D Converter (n = 76): Nonconverter (n = 70)a
 T2D Converter (n = 76): Nonconverter (n = 70)b
 T2D Converter (n = 76): Nonconverter (n = 70)c
Mean ± sd Median Mean ± sd Median OR 95% CI P Valued Odds Ratio 95% CI P Valued OR 95% CI P Valued
Glycine 238 ± 71 227 204 ± 45 197 0.58 0.39–0.88 .0098 0.56 0.36–0.88 .011 0.8026 0.52–1.25 .33
Alanine 359 ± 78 365 405 ± 91 390 1.64 1.10–2.44 .016 1.79 1.15–2.70 .0089 1.4918 0.97–2.30 .069
Serine 98 ± 20 99 92 ± 20 91 0.79 0.53–1.20 .28 0.76 0.49–1.19 .24 0.9165 0.58–1.44 .71
Proline 168 ± 51 162 175 ± 43 166 1.1 0.76–1.59 .61 1.19 0.80–1.79 .39 1.0241 0.69–1.52 .91
Valine 201 ± 36 195 232 ± 36 235 2.22 1.47–3.33 .00010 2.08 1.37–3.23 .00080 1.7731 1.15–2.74 .0099
Leucine or isoleucine 140 ± 30 141 155 ± 30 157 1.59 1.09–2.33 .016 1.47 0.98–2.22 .065 1.3681 0.92–2.03 .12
Methionine 19 ± 6 17 18 ± 5 17 0.7 0.45–1.11 .14 0.67 0.40–1.11 .12 0.6478 0.39–1.06 .087
Histidine 77 ± 13 77 73 ± 14 72 0.78 0.55–1.10 .15 0.75 0.52–1.10 .14 0.8165 0.56–1.18 .28
Phenylalanine 67 ± 13 66 72 ± 12 72 1.56 1.01–2.44 .045 1.72 1.06–2.86 .027 1.1473 0.71–1.85 .57
Tyrosine 72 ± 17 69 78 ± 17 78 1.23 0.85–1.79 .26 1.41 0.93–2.13 .11 0.9307 0.61–1.41 .74
Asparagine and aspartate 55 ± 44 44 35 ± 32 15 0.42 0.24–0.73 .0022 0.41 0.23–0.75 .0036 0.4617 0.27–0.80 .0063
Glutamine and glutamate 97 ± 32 92 112 ± 35 109 1.82 1.16–2.78 .0080 1.75 1.12–2.78 .015 1.4813 0.93–2.37 .10
Ornithine 54 ± 14 52 58 ± 15 59 1.18 0.83–1.69 .36 1.09 0.74–1.59 .67 1.1976 0.83–1.74 .34
Citrulline 33 ± 9 32 33 ± 9 32 1.1 0.77–1.54 .62 1.02 0.70–1.49 .9 1.2642 0.86–1.87 .24
Arginine 80 ± 17 78 86 ± 18 87 1.3 0.90–1.85 .17 1.22 0.83–1.79 .31 1.3363 0.90–1.98 .15

Abbreviations: CI, confidence interval, OR, odds ratio.

a

Covariates: age, sex, BMI, and ethnicity.

b

Covariates: age, sex, BMI, ethnicity, and AIR.

c

Covariates: age, sex, BMI, ethnicity, and SI.

d

Values in bold indicate statistical significance corrected for multiple comparisons (P < 0.0018).