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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Bone Miner Res. 2015 Mar;30(3):550–562. doi: 10.1002/jbmr.2374

Figure 3. Alterations of bone structure in Δ130-136 transgenic mice as shown by MicroCT analysis.

Figure 3

3D microCT analysis of tibial trabecular bone showed that bone volume fraction (BV/TV, A), trabecular thickness (Tb. Th, B) and trabecular number (Tb. N, C) were not significantly different between R76W and Δ130-136 transgenic mouse lines and WT control. MicroCT analysis of tibial midshaft cortical bone showed that total area (T.Ar, D), bone area (B.Ar, E), cortical thickness (Ct. Th, G) and MMI (H) were significantly increased in Δ130-136 mice in comparison to WT and R76W mice, while the ratio of B.Ar to T.Ar (F) was significantly decreased in Δ130-136 mice compared to WT and R76W mice. Data shown are mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001. n = 11-17. The microCT images of cross sections of tibial midshaft cortical bone are shown (I).