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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Bone Miner Res. 2015 Mar;30(3):550–562. doi: 10.1002/jbmr.2374

Figure 4. Alterations of bone structure shown by MicroCT are correlated with the changes of bone material properties in Δ130-136 transgenic mice by three point bending analysis.

Figure 4

MicroCT analysis of femur midshaft cortical bone showed that total area (T.Ar, A), bone area (B.Ar, B) and MMI (C) were significantly increased in Δ130-136 mice in comparison to WT and R76W mice. Data shown are mean ± SD. **, P < 0.01; ***, P < 0.001. n = 11-17. Three-point bending assay was performed on isolated femur bones of 4-month old, male WT and transgenic mice, and stiffness (D), yield force (E), elastic modulus (F) and ultimate tensile strength (G) were measured. Yield force (E) was significantly greater in Δ130-136 mice compared to WT and R76W mice. A significant reduction was observed in the elastic modulus (F) and ultimate tensile strength (G) of Δ130-136 compared to WT and R76W mice. Data shown are mean ± SD. *, P < 0.05; **, P < 0.01. n = 6.