Table 2.

Clinical symptoms at baseline and after total splenectomy or partial splenectomy for children with hereditary spherocytosis or sickle cell disease

	Hereditary spherocytosis			Sickle cell disease
	Baseline	Postop	p-value	Baseline	Postop	p-value
Splenic sequestration	8 (20%)	1 (2.6%)	0.034	45 (90%)	1 (2.1%)	<0.001
Transfusions	8 (20%)	0 (0%)	0.005	13 (26%)	1 (2%)	<0.001
Aplastic or anemic crisis	5 (12.5%)	NR		NR	NR
Hypersplenism	0 (0%)	NR		4 (8%)	NR
Splenomegaly	11 (27.5%)	0 (0%)	<0.001	5 (10%)	0 (0%)	0.025

Numbers represent counts (%) for symptoms at baseline and postoperatively for children with hereditary spherocytosis or sickle cell disease following total splenectomy or partial splenectomy. Transfusions-History of transfusions or participation in regular transfusion program. p-values represent McNemar’s for matched pair differences between baseline and postoperative symptoms. Any symptom reported during 1 year follow-up was counted as having a postoperative symptom, with multiple episodes during follow-up counted only once. NR-Not recorded