. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2014 Sep 15;13(3):561–568.e1. doi: 10.1016/j.cgh.2014.08.039

Table 4.

Changes in liver histology versus weight loss

	Weight loss < 5% or weight gain (n=21)			Weight loss > 5% (n=8)			p-value^** (between groups)
	Week 0	Week 24	p-value^*	Week 0	Week 24	p-value^*	p-value^** (between groups)
NAS Score (0–8)	4.6 (1.5)	4.5 (2.0)	0.90	4.8 (0.9)	4.1 (1.4)	0.28	0.43
Steatosis grade (0–3)	1.9 (0.8)	1.5 (0.8)	0.05	2.3 (0.5)	1.6 (0.7)	0.049	0.35
Lobular inflammation (0–3)	1.6 (0.7)	1.8 (0.8)	0.33	1.5 (0.5)	1.5 (0.5)	1.0	0.62
Hepatocyte ballooning (0–2)	1.1 (0.8)	1.2 (0.7)	0.60	1.0 (0.8)	1.0 (0.5)	1.0	0.77

Data are expressed as mean with standard deviation in parentheses. Abbreviations for tables: NAS, non-alcoholic fatty liver disease activity score.

P-value between week 0 and week 24 determined with paired T-test assuming equal variance between baseline and week 24 groups.

^**

P-value between groups represents change between week 0 and week 24 between 2 groups (group 1: weight loss < 5% or weight gain, group 2: weight loss > 5%) determined with unpaired T-test assuming equal variance between groups.