Table 3.

Adjusted^† odds ratios (95% confidence intervals) of baseline sRAGE with 6 year change (continuous) and incident elevations^‡ in hsCRP (≥3 mg/L) or GGT (≥36 U/L in women and ≥61 U/L in men) at the 6 year follow-up visit

	hsCRP β (95%CI)	GGT β (95%CI)
Log-transformed sRAGE sRAGE (per 1 SD)	0.41 (−0.72–0.88)	0.70 (−1.77–3.17)
	hsCRP OR (95%CI)	GGT OR (95%CI)
Quartile 1(sRAGE 119.4–713.7 pg/mL)	1.02 (0.57–1.85)	1.19 (0.46–3.08)
Quartile 2 (sRAGE 713.8–968.0 pg/mL)	1.28 (0.78–2.11)	0.93 (0.38–2.26)
Quartile 3 (sRAGE 968.1–1272.3 pg/mL)	0.96 (0.59–1.56)	1.31 (0.58–2.96)
Quartile 4 (sRAGE 1272.4–4650.4 pg/mL)	1 (reference)	1 (reference)
P-value for trend*	0.61	0.89

^†Adjusted for age (years), gender (male, female), race-center (Minnesota whites, North Carolina Whites, Maryland whites, North Carolina blacks, Mississippi blacks), smoking status (current, former, never), alcohol use (current, former, never), blood pressure medication use (yes, no), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mg/dL), diabetes status (yes; no), BMI (kg/m²)

^‡Incident elevations were defined as hsCRP ≥3 mg/L or GGT ≥36 U/L in women and ≥61 U/L in men at visit 4 among those with hsCRP <3 mg/L or GGT <36 U/L in women and <61 U/L in men at visit 2”

^*P-value for trend represents linear trend across the medians of sRAGE quartiles.