FIG 7.

Otoferlin KD effect on structure and formation of lateral line, otic vesicle, and semicircular canals. (A) (Upper panel) YO-PRO-1 uptake in injected control larval zebrafish at 120 hpf; (lower panel) YO-PRO-1 uptake in otoferlin b+a double KD larval zebrafish at 120 hpf. (B) Bright-field images showing otic region in 120-h-old injected control (upper panel) and otoferlin b+a double-KD (lower panel) larvae. Open arrowheads point to the otoliths, filled arrowheads point to the semicircular canals, and white circles and hemicircles indicate the position of the eye.