Table 1. HMGA1 in Normal Stem Cells and Cancer Stem Cells.

	Model System	Finding	Citation
HMGA1 in normal embryogenesis, ESCs, and adult stem cells	Murine embryonic stem cells and postnatal tissues	HMGA1 is highly expressed in embryonic development and silenced after birth	Chiappetta et al, 1996 [40]
	Heterozygous and homozygous HMGA1-null mice	HMGA1-null mice develop aberrant hematopoiesis, a myeloproliferative disorder, and a cardiomyopathy	Fedele et al, 2006 [46]
	Human embryonic stem cells and primary tumors	HMGA1 is among a 9 gene transcription factor stem cell signature	Ben-Porath et al, 2008 [9]
	Human hematopoietic stem cells	CD34+ hematopoietic stem cells express HMGA1	Zhou et al, 2001 [41] Karp et al, 2011 [43], Nelson et al, 2011 [44], Chou et al, 2011 [42]
	Lgr5-knock-in (Lgr5-ki) mice	HMGA1 mRNA and protein are enriched in Lgr5+ intestinal stem cells	Munoz et al, 2012 [45]
	Human embryonic stem cells and induced pluripotent stem cells	HMGA1 is highly expressed in ESCs and iPSCs, and expression falls with differentiation	Shah et al, 2012 [10]
HMGA1 in CSCs	Murine model of AML	HMGA1 is among the leukemia stem cell signature	Somervaille et al, 2009 [53]
	Colon cancer cell lines	HMGA1 is required for tumor progression and colon cancer stem cells/tumor-initiator cells	Belton et al, 2012 [11]
	Breast cancer cell lines	HMGA1 is required for tumor progression and breast cancer stem cells/tumor-initiator cells	Shah et al, 2013 [12]