Table 1. In vivo neutralization of HBV infection by monoclonal antibodies (mAbs).
HBV genotype | Group | HB0116 (μg/body) | HB0478 (μg/body) | HBV DNA (copies/mL) |
---|---|---|---|---|
C | Group 1 | - | - | 9.8 × 103 |
(n = 2) | - | - | 1.1 × 104 | |
Group 2 | 1 | - | n.d. | |
(n = 3) | 1 | - | n.d. | |
1 | - | n.d. | ||
Group 3 | 10 | - | n.d. | |
(n = 3) | 10 | - | n.d. | |
10 | - | n.d. | ||
Group 4 | - | 1 | n.d. | |
(n = 3) | - | 1 | n.d. | |
- | 1 | n.d. | ||
Group 5 | - | 10 | n.d. | |
(n = 3) | - | 10 | n.d. | |
- | 10 | n.d. | ||
A | Group 6 | 1 | - | n.d. |
(n = 3) | 1 | - | n.d. | |
1 | - | n.d. | ||
Group 7 | 10 | - | n.d. | |
(n = 3) | 10 | - | n.d. | |
10 | - | n.d. | ||
Group 8 | - | 1 | n.d. | |
(n = 3) | - | 1 | n.d. | |
- | 1 | n.d. | ||
Group 9 | - | 10 | n.d. | |
(n = 2) | - | 10 | n.d. | |
G145R | Group 10 | - | - | 1.4 × 104 |
(n = 2) | - | - | 1.0 × 104 | |
Group 11 | 10 | - | 4.4 × 104 | |
(n = 3) | 10 | - | 1.1 × 104 | |
10 | - | 3.3 × 104 | ||
Group 12 | - | 10 | n.d. | |
(n = 3) | - | 10 | n.d. | |
- | 10 | n.d. | ||
Group 13 | 1 | 1 | n.d. | |
(n = 2) | 1 | 1 | n.d. | |
Group 14 | 10 | 10 | n.d. | |
(n = 2) | 10 | 10 | n.d. | |
Group 15 | - | 1 | n.d. | |
(n = 2) | - | 1 | n.d. |
n.d.: not detected.