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. Author manuscript; available in PMC: 2015 Dec 11.
Published in final edited form as: Oncogene. 2014 Aug 18;34(24):3131–3143. doi: 10.1038/onc.2014.253

Figure 6. NPY promotes survival of chemotherapy-treated NB cells.

Figure 6

A. SK-N-BE(2) cells were cultured in 1% FBS media and treated with cisplatin (0.5μg/ml), doxorubicin (0.5μg/ml), etoposide (2.5μg/ml) or vinblastine (1μg/ml) for 24h with or without 10−7M NPY and Y5R antagonist (10−6M). Cell survival was measured by MTS assay. B. SK-N-BE(2) cells were treated with chemotherapy with or without NPY, as above, and apoptosis was assessed by caspase 3/7 activity assay.