Table 1.

Characteristics of gastrointestinal (extra-gastric) biopsies

Organ/Diagnosis	Criteria
Esophagus
Lymphocytic esophagitis	high numbers of intraepithelial lymphocytes (>50 or more/HPF) with no or rare granulocytes
Granulomatous esophagitis	any type of inflammation associated with granulomas
Reflux esophagitis	intraepithelial eosinophilic and lymphocytic infiltration with basal cell hyperplasia, elongation of papillae, and spongiosis
Eosinophilic esophagitis	severe intraepithelial eosinophilic infiltrate with more than 20 eosinophils per high-power field,
Candidal esophagitis	presence of Candida ± neutrophilic infiltration.
Duodenum and ileum
Granulomatous duodenitis/ileitis	granulomatous inflammation unrelated to crypt rupture
Active duodenitis/ileitis	granulocytic inflammation with epithelial damage.*
Chronic inactive duodenitis/ileitis	increase of chronic inflammation with mild villous blunting without active inflammation
Peptic injury	active duodenitis with gastric foveolar metaplasia
Colorectum
Chronic colitis	quiescent, or mild, or moderate, or severe colitis
Granulomatous colitis	chronic colitis associated with isolated epithelioid granuloma**.

^*Peptic injury with foveolar metaplasia was excluded.

^**Crypt-associated granulomas due to mucin leakage were excluded from this category.