Fig. 2. Minocycline promotes neuronal loss from the ipsilateral dLGN 48 hours after cortical ablation in P10, MT−/− mice.
Using unbiased stereological methods, the number of cresyl violet stained neurons in the contralateral (contra) and ipsilateral (ipsi) dLGN were estimated by an investigator blinded to the treatment condition. At 24 hours post-injury, the number of neurons was unchanged, but by 48 hours post-injury minocycline (MC) treated mice had fewer neurons remaining in the dLGN compared to their saline (Sal) treated counterparts. *P=0.03, saline vs. minocycline, Mann-Whitney U, N= 3 /contra group, N= 5 /ipsi group.