Table 2.
Cox regression analysis of CKD registration within 12 months (1829 events of total n = 12,988)
| Variable | Category | Univariate | Multivariable* | ||||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | p | HR | (95% CI) | p | ||
| Sex (female vs. male) | 1.17 | (1.10-1.27) | 0.001 | 1.19 | (1.08-1.30) | 0.001 | |
| Age (continuous) | 1.00 | (1.00-1.01) | 0.058 | 1.00 | (1.00-1.01) | 0.546 | |
| IMD quintile (vs. least deprived) | 1 (most deprived) | 0.95 | (0.79-1.13) | 0.324 | 0.92 | (0.88-1.13) | 0.381 |
| 2 | 1.08 | (0.94-1.25) | 1.07 | (0.96-1.23) | |||
| 3 | 1.10 | (0.97-1.25) | 1.09 | (0.92-1.23) | |||
| 4 | 1.00 | (0.88-1.13) | 0.99 | (0.77-1.11) | |||
| Cardiovascular disease at baseline (vs no CVD) | 1.19 | (1.10-1.29) | 0.001 | 1.11 | (1.00-1.23) | 0.049 | |
| Diabetes at baseline (vs. no diabetes) | 1.25 | (1.10-1.32) | 0.001 | 1.21 | (1.08-1.37) | 0.002 | |
| Hypertension at baseline (vs. no hypertension) | 1.39 | (1.14-1.32) | <0.001 | 1.36 | (1.23-1.49) | <0.001 | |
| Baseline eGFR (continuous, ml/min/1.73 m2) | 0.99 | (0.99-1.00) | <0.001 | 0.99 | (0.98-0.99) | <0.001 | |
| Year of joining cohort (vs. 2007) | 2008 | 0.67 | (0.53-0.84) | <0.001 | 0.71 | (0.56-0.89) | <0.001 |
| 2009 | 0.54 | (0.43-0.69) | 0.58 | (0.46-0.74) | |||
| 2010 | 0.42 | (0.33-0.54) | 0.44 | (0.34-0.57) | |||
| 2011 | 0.46 | (0.36-0.60) | 0.49 | (0.38-0.63) | |||
| 2012 | 0.41 | (0.33-0.57) | 0.46 | (0.34-0.60) | |||
*adjusted for age, sex, index of multiple deprivation, cardiovascular disease, hypertension, diabetes, baseline eGFR, year of joining cohort.
Abbreviations in Table 3: CKD chronic kidney disease, IMD Index of multiple deprivation, BP blood pressure, eGFR estimated Glomerular Filtration Rate, CVD cardiovascular disease.