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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: J Infect Dis. 2006 Sep 12;194(8):1127–1134. doi: 10.1086/507907

Figure 1. Ex vivo whole-blood cytokine response and Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) single-nucleotide polymorphism (SNP) C558T.

Figure 1

Whole blood was harvested from individuals with TIRAP genotypes 558CC (black circles) or 558TT (white circles). Cells were stimulated with 80 or 320 ng/mL lipopeptides PAM2Cys-SKKK (PAM2) or PAM3Cys-SKKK (PAM3) (A), 10 ng/mL lipopolysaccharide (LPS) (B), PBS, or 25 or 100 μg/mL whole-cell H37Rv Mycobacterium tuberculosis (TB) lysates (C). Cells were stimulated for 18 h, and supernatants were assayed for cytokine production by ELISA. Data are combined from 2 separate experiments, each of which were performed in triplicate. Individual data points are plotted, with the median indicated by a line. Significant P values are noted and were calculated using the Mann-Whitney U test.

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