Table 2. Genome-wide significant associations from the GWAS of PACG.
| GWAS (stage 1) |
Replication (stage 2) |
All data (stages 1 and 2) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome | SNP | Gene | A1 | OR | P | OR | P | OR | P | P het | I2 (%) |
| 11 | rs11024102 | PLEKHA7 | G | 1.27 | 1.43 × 10−8 | 1.18 | 3.72 × 10−5 | 1.22 | 5.33 × 10−12 | 0.64 | 0 |
| 1 | rs3753841 | COL11A1 | G | 1.22 | 2.82 × 10−6 | 1.18 | 6.62 × 10−5 | 1.20 | 9.22 × 10−10 | 0.59 | 0 |
| 8 | rs1015213 | PCMTD1-ST18 | A | 1.56 | 3.90 × 10−6 | 1.44 | 1.77 × 10−4 | 1.50 | 3.29 × 10−9 | 0.19 | 19.0 |
A1, effect allele; OR, per-allele odds ratio of the effect allele; P, P value for association; Phet, P value for heterogeneity between collections; I2, I-squared index quantifying heterogeneity (Online Methods).