Table 4. Top 100 differentially abundant transcripts in samples from patients with uncomplicated dengue collected on day 4 relative to samples from patients with dengue shock syndrome collected on day 4.
| GenBank | Symbol | Fold changea | Function |
|---|---|---|---|
| NM_005623 | CCL8 | +170.64 | Chemokino (C-C motil) ligand 8 |
| NM_002982 | CCL2 | +86.95 | Chemokine (C-C motif) ligand 2 |
| NM_199204 | DHRS9 | +32.46 | Dehydrogenase/reductase (SDR family) member 9 |
| NM_004972 | JAK2 | +21.92 | Janus kinase 2 (a protein tyrosine kinase) |
| NM_002164 | INDO | +17.36 | Indoleamine-pyrrole 2,3 dioxygenase |
| NM_000067 | CA2 | +16.66 | Carbonic anhydrase II |
| NM_001565 | CXCL 10 | +16.26 | Chemokine (C-X-C motif) ligand 10 |
| NM_003865 | HESX1 | +12.45 | HESX homeobox 1 |
| NM_004657 | SDPR | +11.5 | Serum deprivation response (phosphatidylserine-binding protein) |
| NM_002053 | GBP1 | +10.68 | Guanylate binding protein 1, interferon inducible, 67 kDa |
| NM_002024 | FMR1 | +10.27 | Fragile X mental retardation 1 |
| NM_033238 | PML | +9.61 | Promyelocytic leukemia |
| XM_038864 | KIAA1632 | +8.13 | Homo sapiens KIAA1632 (KIAA1632), mRNA |
| XM_293276 | LOC347348 | +8.13 | … |
| NM_002729 | HHEX | +8.06 | Homeobox, hematopoietically expressed |
| NM_006079 | CITED2 | +7.87 | Cbp/p300-interacting transactivator with Glu/Asp rich carboxy-terminal domain, 2 |
| NM_014398 | LAMP3 | +7.57 | Lysosomal-associated membrane protein 3 |
| NM_030881 | DOX17 | +6.84 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 |
| NM_012329 | MMD | +6.71 | Monocyte to macrophage differentiation associated |
| NM_014016 | SACM1L | +6.62 | … |
| NM_001547 | IFIT2 | +6.62 | Interferon-induced protein with tetratricopeptide repeats 2 |
| XM_209643 | LOC285510 | +6.49 | … |
| NM_018682 | MLL5 | +6.02 | Myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) |
| NM_181291 | WDR20 | +5.88 | Wd repeat domain 20 |
| NM_144590 | MGC22805 | +5.78 | Ankyrin repeat domain 22 |
| NM_006887 | ZFP36L2 | +5.71 | Zinc finger protein 36, C3H type–like 2 |
| NM_017719 | SNRK | +5.64 | SNF-related kinase |
| NM_174938 | FRMD3 | +5.61 | Ferm domain containing 3 |
| NM_000161 | GCH1 | +5.61 | GTP cyclohydrolase 1 (dopa-responsive dystonia) |
| NM_032860 | C6orf93 | +5.55 | Chromosome 6 open reading frame 93 |
| NM_003489 | NRIP1 | +5.37 | Nuclear receptor-interacting protein 1 |
| XM_059368 | LOC129607 | +5.23 | … |
| NM_021170 | Hes4 | +5.2 | Hairy and enhancer of split 4 (Drosophila) |
| NM_175862 | CD86 | +5.12 | CD86 antigen (CD28 antigen ligand 2, B7–2 antigen) |
| NM_014857 | HHL | +4.97 | RAB GTPase activating protein 1–like |
| NM_017631 | FLJ20035 | +4.97 | Hypothetical protein FLJ20035 |
| NM_006276 | SFRS7 | +4.95 | … |
| NM_016135 | ETV7 | +4.92 | ets variant gene 7 (TEL2 oncogene) |
| NM_000584 | IL8 | +4.9 | Interleukin 8 |
| NM_006022 | TSC22 | +4.73 | TSC22 domain family, member 1 |
| NM_003473 | STAM | +4.65 | Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| MM_153045 | C9orf91 | +4.62 | Chromosome 9 open reading frame 91 |
| NM_004099 | STOM | +4.58 | Stomatin |
| NM_147128 | LOC223082 | +4.52 | … |
| NM_021105 | PLSCR1 | +4.48 | Phospholipid scramblase 1 |
| NM_033220 | TRIM14 | +4.46 | Tripartite motif containing 14 |
| NM_000689 | ALDH1A1 | +4.42 | Aldehyde dehydrogenase 1 family, member A1 |
| NM_145804 | ABTB2 | +4.42 | Ankyrin repeat and BTB (POZ) domain containing 2 |
| NM_018847 | KIAA1354 | +4.38 | Kelch-like 9 (Drosophila) |
| NM_178237 | SEC3L1 | +4.36 | … |
| NM_181782 | NCOA7 | +4.31 | … |
| NM_037817 | FLJ31033 | +4.31 | Hypothetical protein FLJ31033 |
| NM_000076 | CDKN1C | +4.31 | Cyclin dependent kinase inhibitor 1C (p57, Kip2) |
| NM_0O4842 | AKAP7 | +4.27 | A kinase (PRKA) anchor protein 7 |
| NM_003745 | SOCS1 | +4.25 | Suppressor of cytokine signaling 1 |
| NM_017837 | FLJ20477 | +4.21 | Phosphatidylinositol glycan, class V |
| NM_002835 | PTPN12 | +4.21 | Protein tyrosine phosphatase, nonreceptor type 12 |
| NM_173842 | IL 1RN | +4.2 | Interleukin 1 receptor antagonist |
| NM_022168 | MDA5 | +4.16 | Interferon induced with helicase C domain 1 |
| MM_199324 | HSHIN1 | +4.14 | OTU domain containing 4 |
| NM_001981 | EPS15 | +4.14 | Epidermal growth factor receptor pathway substrate 15 |
| NM_001735 | C5 | +4.13 | Complement component 5 |
| NM_002145 | HOXB2 | +4.11 | Homeobox 82 |
| NM_014314 | RIG-1 | +4.08 | Dead (AspGIu-Ala-Asp) box polypeptide 58 |
| NM_001186 | BACH1 | +4.04 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 |
| NM_052941 | GBP4 | +4.03 | Guanylate binding protein 4 |
| NM_014358 | CLECSF9 | +4.03 | C-type lectin domain family 4, member E |
| NM_001712 | CEACAM1 | +3.92 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| NM_006074 | TRIM22 | +3.92 | Tripartite motif-containing 22 |
| NM_153341 | IBRDC3 | +3.9 | IBR domain containing 3 |
| NM_006415 | SPTLC1 | +3.87 | Serine palmitoyltransferase, long chain base subunit 1 |
| NM_001548 | IFIT1 | +3.83 | Interferon-induced protein with tetratnucleopeptide repeats 1 |
| NM_152522 | MGC33864 | +3.83 | ADP-ribosylation–like factor 6 interacting protein 6 |
| NM_020423 | PACE-1 | +3.81 | … |
| NM_013352 | SART2 | +3.81 | Squamous cell carcinoma antigen recognized by T cells 2 |
| NM_006018 | HM74 | +3.78 | G protein–coupled receptor 109B |
| NM_018993 | RIN2 | +3.77 | Ras and Rab interactor 2 |
| XM_353706 | LOC378204 | +3.74 | … |
| NM_017414 | USP18 | +3.74 | Ubiquitin-specific peptidase 18 |
| NM_015589 | SAMD4 | +3.71 | Sterile alpha motil domain containing 4 |
| NM_004241 | TRIP8 | +3.67 | Jumonji domain containing 1C |
| NM_006667 | PGRMC1 | +3.64 | Progesterone receptor membrane component 1 |
| NM_052942 | GBP5 | +3.63 | Guanylate binding protein 5 |
| NM_004863 | SPTLC2 | +3.63 | Serine palmitoyltransferase, long chain base subunit 2 |
| NM_153374 | MGC35274 | +3.62 | LysM, putative peptidoglycan binding, domain containing 2 |
| NM_021127 | PMAIP1 | +3.61 | Phorbol-12-myristate-13-acetate–induced protein 1 |
| NM_007268 | Z39IG | −15.82 | V-set and immunoglobulin domain containing 4 |
| NM_002417 | MKI67 | −9.91 | Antigen identified by monoclonal antibody Ki-67 |
| NM_005480 | TROAP | −8.27 | Trophinin associated protein (tastin) |
| NM_003088 | FSCN1 | −6.93 | Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) |
| NM_000478 | ALPL | −5.4 | Alkaline phosphatase, liver/bone/kidney |
| NM_002343 | LTF | −5.37 | Lactotransferrin |
| NM_015671 | DKFZP434J046 | −5.17 | Chromosome 19 open reading frame 14, homo sapiens WD repeat domain 62 (WDR62), mRNA |
| NM_005091 | PGLYRP1 | −4.79 | Peptidoglycan recognition protein 1 |
| NM_001925 | DEFA4 | −4.48 | Defensin, alpha 4, corticostatin |
| NM_005217 | DEFA3 | −4.28 | Defensin, alpha 3, neutrophil-specific |
| NM_004260 | RECQL4 | −4.04 | RecQ protein–like 4 |
| NM_021953 | FOXM1 | −3.77 | … |
| NM_002466 | MYBL2 | −3.73 | v-myb myeloblastosis viral oncogene homolog (avian)–like 2 |
| NM_002997 | SDC1 | −3.61 | Syndecan 1 |
a
Fold changes reflect greater (positive fold change) or lesser (negative fold change) abundance in acute samples from uncomplicated dengue patients.