Table 1. Combination index for IFN-α and IFN-λ1 against CCHF replication respectively in A549 and HuH-7 cells.
| IFN-α | IFN-λ1 | Combination Index* | |
|---|---|---|---|
| (IU/ml) | (ng/ml) | A549 | HuH-7 |
| 1.0 | 0.01 | 582.8 | 1.08E14 |
| 10.0 | 0.1 | 103,469 | 3.04E13 |
| 100.0 | 1.0 | 9.25E7 | 3.55E20 |
| 1000.0 | 10.0 | 5,008,013 | 1.19E14 |
*The Combination Index (CI) was calculated using the CompuSyn software (Chou, T.-C. and Martin, N. CompuSyn software for drug combinations and for general dose effect analysis, and user’s guide. ComboSyn, Inc. Paramus, NJ 2007. [www.combosyn.com]) which uses the method of Chou & Talalay. CI values <1, 1 and >1 indicate synergism, additive effect and antagonism, respectively.