Table 4.

Additional ways to modulate the immune system. The table summarizes the various strategies that have been proposed to reduce or eliminate a immune rejection of cells. Some of these strategies are only possible with pluripotent cells and some require extensive gene engineering. For detail see text and references

Ensuring survival of transplanted cells
• Autologous or Syngeneic transplant
• Transplant in utero
• Transplant to an immune privileged site
• Co-transplant of immune modulatory cells
• Localized immunesuppression (Indoleamine, NO, HLA-G)
• CTL blockade, anti-TCR therapy
• ABO tolerization and other antigen tolerization
• T-regs- (CD24-) to induce tolerization
• Mixed chimerism with accompanied bone marrow transplant
• iPSC engineering
• Generation of DC cells
• Thymic rejuvenation
• HLA matching with immune suppression