Fig. 2.

Prediction-corrected visual predictive check of the final RIF plasma, ELF and AC pharmacometric submodels. The open circles are the population prediction-corrected observations. The solid line is the median of the observed data and the dashed lines are the 5th and 95th percentiles of the observed data. The top and bottom shaded areas are the 95 % confidence intervals for the 5th percentile and the 95th percentile of simulated data. The middle shaded area is the 95 % confidence interval for the median of the simulated data