FIG. 2.
Effect of systemic BMMSC infusion on BMMSC-mediated subcutaneous bone formation in C57BL/6J mice. (A) Histological structure of subcutaneous implantation in immunocompromised mice at 8 weeks post-BMMSC/HA/TCP implantation. (B) Histological structure of subcutaneous implantation in C57BL/6J mice. (C) Histological structure of subcutaneous implantation in C57BL/6J mice after 1×106 BMMSCs systemic infusion. (D) ImageJ semiquantitative analysis indicated the amount of bone formation in BMMSC implants. New bone (Bone), connective tissue (CT), HA/TCP (HA), **p<0.01, n=5. Scale bar=100 μm. HA/TCP, hydroxyapatite/tricalcium phosphate. Color images available online at www.liebertpub.com/tea