Figure 1.

Distinct epigenome landscapes between EZH2 ensemble (a) and solo peaks (b). Ensembl and solo peaks were defined by Xu et al. from prostate cancer cell line Abl (16). For each EZH2 peak, we took the peak center and then extended 1-kb to up- and downstream. In the heatmap, each row is a dataset and each column is genomic position around EZH2 peak center. Signals of each dataset were normalized into range (0,1). Magenta and cyan colors indicate high and low signals, respectively. All ChIP-seq data were generated from Abl cell line. CpG density was computed from the human reference genome (hg19/GRCh37) and PhastCon score was downloaded from UCSC annotation database. Both heatmaps were generated by Epidaurus.